The comedy icons will be leading the show from Los Angeles and New York.
The Hollywood Foreign Press Association confirmed to ET on Tuesday that Fey will be hosting from the iconic Rainbow Room in Manhattan, while Poehler will be holding things down from the Beverly Hilton -- the usual home of the star-studded awards show.
Meanwhile, the presenters and nominees will be participating from various locations around the country, as the ceremony adapts to the unusual conditions of the coronavirus pandemic.
This year's show had to be pushed back from its typical January date -- while a number of other awards shows have been postponed as well, including the GRAMMYs, now set for March 14, and the Oscars, which are scheduled for April 25. See the full 2021 awards season calendar here.